Aspartaam en kanker
 

Sweetener manufacturer disputes validity of new health research

[size=5]Study links aspartame with cancers[/size]
Ingredient used in more than 6,000 products

Felicity Lawrence
Friday September 30, 2005
The Guardian



Aspartame, the artificial sweetener used in more than 6,000 food and drink products around the world, is the subject of renewed controversy this week after the results of the latest research into whether it can cause cancer.

Scientists at the independent European Ramazzini Foundation for cancer research in Bologna presented new results from its long-term, large-scale study of the effect of aspartame on 1,800 rats, at its international conference on cancer and environmental sciences in Italy last week.

The research centre said analysis of its latest results showed aspartame caused cancer of the kidney, and of the peripheral nerves, mainly in the head. Earlier data from the same study published in July linked aspartame to an increased risk of leukaemias and lymphomas in female lab rats "at doses very close to the acceptable daily intake for humans".


Manufacturers of the sweetener have challenged the validity of the study. They say the research is "in total conflict with hundreds of credible studies that have been thoroughly reviewed by the regulatory authorities around the world" and that "the allegations are inconsistent with human epidemiological data". They question the record of the institute and say it is "criminal" for it to present its data publicly before it had made it all available to the regulatory authorities and before it had been fully reviewed.

Aspartame is roughly 200 times sweeter than sugar. It is regularly consumed by more than 350 million people worldwide, and is estimated to account for 62% of the market in sweetening agents. It is commonly found in the UK in diet colas and other low-calorie drinks, juices, sweets, chewing gum, cereals, yoghurts, other desserts, snack foods such as crisps, medicines and vitamin supplements, including those for children.

The European Food Safety Authority is not at present recommending any change in consumers' diets. "Up to now aspartame has been considered safe, based on the studies available," it said. It would review the research "as a matter of high priority, in the context of previous extensive safety data available on aspartame".

Aspartame has been authorised for use in foods for a long time but has a "controversial history", according to EFSA. Because it is widely consumed, particularly by young children and pregnant women, the European Ramazzini Foundation decided to carry out an unusually large study of feeding aspartame to laboratory rats, according to its director, Dr Morando Soffritti.

The rats were studied for nearly three years, until the end of their natural lifespan; most studies last about two years. Six different dose levels were tested against a control group not given aspartame. The National Toxicology Programme of the US National Institutes of Health convened a pathology working group to provide a second opinion on the interpretation of some of the cancerous lesions observed by the Ramazzini researchers, and helped with the statistical evaluation of data.

The Italian scientists concluded that aspartame is a "multipotential carcinogen", causing a dose-related increase in leukaemias and lymphomas in female rats, and a dose-related increase in incidence of cancer and its precursors in the kidney (renal pelvis and ureter) as well as tumours in the peripheral nerves, in particular in cranial nerves.

Aspartame is metabolised into aspartic acid, phenylalanine and methanol. Methanol is in turn metabolised to formaldehyde. Previous large-scale experiments by the Ramazzini Foundation have linked both methanol and formaldehyde to a significant increase of leukaemias and lymphomas, the researchers say. However, they point out that the other sorts of cancer they observed in their aspartame study did not show up in studies on methanol and formaldehyde, suggesting an urgent need to study whether aspartic acid or phenylalanine were also potential carcinogens.

The researchers also found that while rats fed aspartame ate less food, there was no difference in weight between treated and untreated animals. The first results have been published in the foundation's journal, the European Journal of Oncology, and have been peer-reviewed by seven international experts, according to the journal's editorial board. The second results have not yet been peer-reviewed.

The foundation is now planning to enlarge its study to embryonic rats and mice - work that will take several years to complete. Meanwhile, one of the authors of the study, Fiorella Belpoggi said: "In our opinion, the results of our first experiment on aspartame call for urgent reconsideration of the rules governing its use as an artificial sweetener."

One of the largest manufacturers of aspartame, Ajinomoto, the Japanese multinational which also makes monosodium glutamate, has challenged the research. Its senior scientists said they did not agree with the interpretation of results, nor did they believe that the study's protocols met internationally approved standards. They said the results were not statistically significant, that numerous studies had shown aspartame was safe, and that regulatory bodies around the world had concluded it was safe.

"Aspartame has a record of 25 years of safe use. Aspartame is made from amino acids and is broken down into common dietary components. Aspartame itself therefore brings nothing new to the diet," a spokesman said. "Raising ill-founded fears about an ingredient which helps people to control calorie intake is not benign."

The International Sweeteners Association said last week: "Aspartame is one of the most tested food ingredients ever and all evaluations undertaken by independent risk assessors at international, European, and national level have concluded that aspartame is a safe foodstuff ... Aspartame can make a useful contribution to weight control. With billions of man-years of safe use, there is no indication of an association between aspartame and cancer in humans."

Aspartame was approved for use by the US Food and Drug Administration in 1981, and for use in soft drinks a couple of years later. The FDA looked at four previous studies conducted for the industry on whether aspartame causes cancer.

One had reported an increase in brain tumours in rats, although the FDA ruled that parts of the study were flawed. Three others concluded it was not carcinogenic. When the FDA reviewed all the data, it concluded that there was no evidence of a carcinogenic effect on the brains of animals. A review of all the data on aspartame was carried out in 2002 by the European commission's scientific committee on food. It concluded that it was safe and reconfirmed the previously established acceptable daily intake of the additive.

Speaking on behalf of Ajinomoto, Ewan Currie, of the Aspartame Information Service, said: "We are confident that when it has been scrutinised by third parties, aspartame will be exonerated."





U drinkt toch ook uw dagelijkse dosis kanker liquide ?[edit]
[size=1]Edit:[/size]

[size=1]After edit by /\|cazar on 05-10-2005 at 13:18 Reason: -------------------------------- Sweetener manufacturer disputes validity of new health research [size=5]Study links aspartame with cancers[/size] Ingredient used in more than 6,000 products Felicity Lawrence Friday September 30, 2005 The Guardian Aspartame, the artificial sweetener used in more than 6,000 food and drink products around the world, is the subject of renewed controversy this week after the results of the latest research into whether it can cause cancer. Scientists at the independent European Ramazzini Foundation for cancer research in Bologna presented new results from its long-term, large-scale study of the effect of aspartame on 1,800 rats, at its international conference on cancer and environmental sciences in Italy last week. The research centre said analysis of its latest results showed aspartame caused cancer of the kidney, and of the peripheral nerves, mainly in the head. Earlier data from the same study published in July linked aspartame to an increased risk of leukaemias and lymphomas in female lab rats "at doses very close to the acceptable daily intake for humans". Manufacturers of the sweetener have challenged the validity of the study. They say the research is "in total conflict with hundreds of credible studies that have been thoroughly reviewed by the regulatory authorities around the world" and that "the allegations are inconsistent with human epidemiological data". They question the record of the institute and say it is "criminal" for it to present its data publicly before it had made it all available to the regulatory authorities and before it had been fully reviewed. Aspartame is roughly 200 times sweeter than sugar. It is regularly consumed by more than 350 million people worldwide, and is estimated to account for 62% of the market in sweetening agents. It is commonly found in the UK in diet colas and other low-calorie drinks, juices, sweets, chewing gum, cereals, yoghurts, other desserts, snack foods such as crisps, medicines and vitamin supplements, including those for children. The European Food Safety Authority is not at present recommending any change in consumers' diets. "Up to now aspartame has been considered safe, based on the studies available," it said. It would review the research "as a matter of high priority, in the context of previous extensive safety data available on aspartame". Aspartame has been authorised for use in foods for a long time but has a "controversial history", according to EFSA. Because it is widely consumed, particularly by young children and pregnant women, the European Ramazzini Foundation decided to carry out an unusually large study of feeding aspartame to laboratory rats, according to its director, Dr Morando Soffritti. The rats were studied for nearly three years, until the end of their natural lifespan; most studies last about two years. Six different dose levels were tested against a control group not given aspartame. The National Toxicology Programme of the US National Institutes of Health convened a pathology working group to provide a second opinion on the interpretation of some of the cancerous lesions observed by the Ramazzini researchers, and helped with the statistical evaluation of data. The Italian scientists concluded that aspartame is a "multipotential carcinogen", causing a dose-related increase in leukaemias and lymphomas in female rats, and a dose-related increase in incidence of cancer and its precursors in the kidney (renal pelvis and ureter) as well as tumours in the peripheral nerves, in particular in cranial nerves. Aspartame is metabolised into aspartic acid, phenylalanine and methanol. Methanol is in turn metabolised to formaldehyde. Previous large-scale experiments by the Ramazzini Foundation have linked both methanol and formaldehyde to a significant increase of leukaemias and lymphomas, the researchers say. However, they point out that the other sorts of cancer they observed in their aspartame study did not show up in studies on methanol and formaldehyde, suggesting an urgent need to study whether aspartic acid or phenylalanine were also potential carcinogens. The researchers also found that while rats fed aspartame ate less food, there was no difference in weight between treated and untreated animals. The first results have been published in the foundation's journal, the European Journal of Oncology, and have been peer-reviewed by seven international experts, according to the journal's editorial board. The second results have not yet been peer-reviewed. The foundation is now planning to enlarge its study to embryonic rats and mice - work that will take several years to complete. Meanwhile, one of the authors of the study, Fiorella Belpoggi said: "In our opinion, the results of our first experiment on aspartame call for urgent reconsideration of the rules governing its use as an artificial sweetener." One of the largest manufacturers of aspartame, Ajinomoto, the Japanese multinational which also makes monosodium glutamate, has challenged the research. Its senior scientists said they did not agree with the interpretation of results, nor did they believe that the study's protocols met internationally approved standards. They said the results were not statistically significant, that numerous studies had shown aspartame was safe, and that regulatory bodies around the world had concluded it was safe. "Aspartame has a record of 25 years of safe use. Aspartame is made from amino acids and is broken down into common dietary components. Aspartame itself therefore brings nothing new to the diet," a spokesman said. "Raising ill-founded fears about an ingredient which helps people to control calorie intake is not benign." The International Sweeteners Association said last week: "Aspartame is one of the most tested food ingredients ever and all evaluations undertaken by independent risk assessors at international, European, and national level have concluded that aspartame is a safe foodstuff ... Aspartame can make a useful contribution to weight control. With billions of man-years of safe use, there is no indication of an association between aspartame and cancer in humans." Aspartame was approved for use by the US Food and Drug Administration in 1981, and for use in soft drinks a couple of years later. The FDA looked at four previous studies conducted for the industry on whether aspartame causes cancer. One had reported an increase in brain tumours in rats, although the FDA ruled that parts of the study were flawed. Three others concluded it was not carcinogenic. When the FDA reviewed all the data, it concluded that there was no evidence of a carcinogenic effect on the brains of animals. A review of all the data on aspartame was carried out in 2002 by the European commission's scientific committee on food. It concluded that it was safe and reconfirmed the previously established acceptable daily intake of the additive. Speaking on behalf of Ajinomoto, Ewan Currie, of the Aspartame Information Service, said: "We are confident that when it has been scrutinised by third parties, aspartame will be exonerated." U drinkt toch ook uw dagelijkse dosis kanker liquide ?[/size]

[size=1]Before any edits, post was: -------------------------------- [font=Arial][size=5]Sweetener manufacturer disputes validity of new health research[/size][/font] [font=arial,helvetica,sans-serif][size=3]· Study links aspartame with cancers · Ingredient used in more than 6,000 products[/size][/font] [font=Geneva,Arial,sans-serif][size=2]Felicity Lawrence Friday September 30, 2005 The Guardian [/size][/font] [font=Geneva,Arial,sans-serif][size=2]Aspartame, the artificial sweetener used in more than 6,000 food and drink products around the world, is the subject of renewed controversy this week after the results of the latest research into whether it can cause cancer. Scientists at the independent European Ramazzini Foundation for cancer research in Bologna presented new results from its long-term, large-scale study of the effect of aspartame on 1,800 rats, at its international conference on cancer and environmental sciences in Italy last week. The research centre said analysis of its latest results showed aspartame caused cancer of the kidney, and of the peripheral nerves, mainly in the head. Earlier data from the same study published in July linked aspartame to an increased risk of leukaemias and lymphomas in female lab rats "at doses very close to the acceptable daily intake for humans". Manufacturers of the sweetener have challenged the validity of the study. They say the research is "in total conflict with hundreds of credible studies that have been thoroughly reviewed by the regulatory authorities around the world" and that "the allegations are inconsistent with human epidemiological data". They question the record of the institute and say it is "criminal" for it to present its data publicly before it had made it all available to the regulatory authorities and before it had been fully reviewed. Aspartame is roughly 200 times sweeter than sugar. It is regularly consumed by more than 350 million people worldwide, and is estimated to account for 62% of the market in sweetening agents. It is commonly found in the UK in diet colas and other low-calorie drinks, juices, sweets, chewing gum, cereals, yoghurts, other desserts, snack foods such as crisps, medicines and vitamin supplements, including those for children. The European Food Safety Authority is not at present recommending any change in consumers' diets. "Up to now aspartame has been considered safe, based on the studies available," it said. It would review the research "as a matter of high priority, in the context of previous extensive safety data available on aspartame". Aspartame has been authorised for use in foods for a long time but has a "controversial history", according to EFSA. Because it is widely consumed, particularly by young children and pregnant women, the European Ramazzini Foundation decided to carry out an unusually large study of feeding aspartame to laboratory rats, according to its director, Dr Morando Soffritti. The rats were studied for nearly three years, until the end of their natural lifespan; most studies last about two years. Six different dose levels were tested against a control group not given aspartame. The National Toxicology Programme of the US National Institutes of Health convened a pathology working group to provide a second opinion on the interpretation of some of the cancerous lesions observed by the Ramazzini researchers, and helped with the statistical evaluation of data. The Italian scientists concluded that aspartame is a "multipotential carcinogen", causing a dose-related increase in leukaemias and lymphomas in female rats, and a dose-related increase in incidence of cancer and its precursors in the kidney (renal pelvis and ureter) as well as tumours in the peripheral nerves, in particular in cranial nerves. Aspartame is metabolised into aspartic acid, phenylalanine and methanol. Methanol is in turn metabolised to formaldehyde. Previous large-scale experiments by the Ramazzini Foundation have linked both methanol and formaldehyde to a significant increase of leukaemias and lymphomas, the researchers say. However, they point out that the other sorts of cancer they observed in their aspartame study did not show up in studies on methanol and formaldehyde, suggesting an urgent need to study whether aspartic acid or phenylalanine were also potential carcinogens. The researchers also found that while rats fed aspartame ate less food, there was no difference in weight between treated and untreated animals. The first results have been published in the foundation's journal, the European Journal of Oncology, and have been peer-reviewed by seven international experts, according to the journal's editorial board. The second results have not yet been peer-reviewed. The foundation is now planning to enlarge its study to embryonic rats and mice - work that will take several years to complete. Meanwhile, one of the authors of the study, Fiorella Belpoggi said: "In our opinion, the results of our first experiment on aspartame call for urgent reconsideration of the rules governing its use as an artificial sweetener." One of the largest manufacturers of aspartame, Ajinomoto, the Japanese multinational which also makes monosodium glutamate, has challenged the research. Its senior scientists said they did not agree with the interpretation of results, nor did they believe that the study's protocols met internationally approved standards. They said the results were not statistically significant, that numerous studies had shown aspartame was safe, and that regulatory bodies around the world had concluded it was safe. "Aspartame has a record of 25 years of safe use. Aspartame is made from amino acids and is broken down into common dietary components. Aspartame itself therefore brings nothing new to the diet," a spokesman said. "Raising ill-founded fears about an ingredient which helps people to control calorie intake is not benign." The International Sweeteners Association said last week: "Aspartame is one of the most tested food ingredients ever and all evaluations undertaken by independent risk assessors at international, European, and national level have concluded that aspartame is a safe foodstuff ... Aspartame can make a useful contribution to weight control. With billions of man-years of safe use, there is no indication of an association between aspartame and cancer in humans." Aspartame was approved for use by the US Food and Drug Administration in 1981, and for use in soft drinks a couple of years later. The FDA looked at four previous studies conducted for the industry on whether aspartame causes cancer. One had reported an increase in brain tumours in rats, although the FDA ruled that parts of the study were flawed. Three others concluded it was not carcinogenic. When the FDA reviewed all the data, it concluded that there was no evidence of a carcinogenic effect on the brains of animals. A review of all the data on aspartame was carried out in 2002 by the European commission's scientific committee on food. It concluded that it was safe and reconfirmed the previously established acceptable daily intake of the additive. Speaking on behalf of Ajinomoto, Ewan Currie, of the Aspartame Information Service, said: "We are confident that when it has been scrutinised by third parties, aspartame will be exonerated." U drinkt toch ook uw dagelijkse dosis kanker liquide ? [/size][/font][/size]

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1. Elke stof is toxisch.

2. Over aspartaam is al zeer veel gezegd en geschreven. Het merendeel is zeer tendentieus (vanuit beide richtingen, zowel voor- als tegenstanders), en het is zeer moeilijk om door de bomen het bos nog te zien.

3. Als u het mij vraagt, is het even ongezond om vijf liter regular coke te drinken per dag, als vijf liter diet coke.

Men schrijft daar wel af en toe iets over, soms krijg je het er van en andere zeggen dan weer het tegenovergestelde dus ik weet het niet meer.
Maar zwaarlijvigheid is een serieuze epidemie aan het worden. Verhoudings gewijs zijn er al even veel kinderen in nederland als in amerika die er mee te kampen heeft.
Niet alleen dik zijn telt, ook krijgen kinderen nu ouderdoms diabetes! En dat ligt 100% aan de voeding. En te weinig sport of gewone beweging.
Dus wie een dieet volgt of al gevolgd heeft weet dat je van suikers en vet verdikt en dan kan volgens mij aspartaam toch beter wat meer gebruikt worden dan suikers.
(by the way 7/10 natuursalade's van mc donalds of een ander wordt stiekem gesuikerd)
En vervang eens vlees door vis en vet of drankjes door water, smakelijk wat minder maar je zal er nog zo content van lopen. Kilo's vliegen er vanzelf af!

Dit verband is inderdaad gevonden maar ik dacht dat het al lang geweten was?

De huidige gebruikte suikervervangers zoals aspartaam zijn lichaamsvreemde stoffen, en lichaamsvreemde stoffen zijn altijd kankerverwekkend. Drink dat goedje dus met mate, en weet dat uiteindelijk de term 'light' voor je lichaam heel weinig verschil uitmaakt, maar veeleer een verzonnen marketingterm is om de omzetcijfers wat op te krikken.
Suiker blijft tenslotte suiker voor je lichaam.

De light coke drinken is ongezonder, vanwege het feit dat aspartaam een lichaamsvreemde stof is dus.

Maar teveel suiker binnenkrijgen is over het algmeen ongezond omdat het, in een eerste fase vermoeidheid, en nadien de kans op zwaarlijvigheid en diabetes verhoogd!

P.S.: Alle koolsoorten, rode biet, broccoli en dergelijke bevatten veel anti-oxidanten en zijn dus goed ter voorkoming van kanker.

En voor de mannen; zink + selenium + zonnebloempitjes en een lepel haver iedere dag "voor de studs"

altijd al geweten dat aspartaam de grootst mogelijke rotzooi is

best ruwe rietsuiker gebruiken

witte suiker is ook rommel !

ik knabbel iedere dag een staafje zink !

beste is natuurhoning.

heeft geen processing ondergaan.

En sinds wanneer is d�*t nu weer de nieuwe gangbare wetenschappelijke hypothese? Die zou dan eerst moeten uitgaan van de definitie van "lichaamsvreemd" natuurlijk (bedoel je daar xenobiotisch mee ?). Ik denk echter dat je verwijst naar stoffen die de mens niet "van nature" naar binnen zou krijgen ?

het ware interessant het onderzoeksrapport eens zelf te lezen ...

FF een wikipedia citaatje.

awel ik behoor dan tot die minderheid, ik vind de smaak ervan echt niet te doen, walgelijk, ik krijg het zelfs niet binnen als ik niks anders heb, ik proef het ook meteen als het me voorgezet wordt zonder dan ik het weet. Het is gewoon qua smaak het slechtste wat ik al proefde.

ik heb dat ook.

precies behanglijm dat ik drink.

Cola light smaakt als een nat tapijt waar je aan slurpt.

Daar zou ik mee opletten. Zink in vaste vorm als metaal kan dodelijk inwerken. Ook de vrijgekomen dampen bij verhitting. ( traag, maar toch)

Ik vind dat ook walgelijk.

Maar wat ik nog erger vindt is dat vriendinnen me vertellen dat de smaak wel went nadat je er veel van drinkt ...

Dat klopt. Zelfs water, dat heeft -heb ik me destijds laten vertellen door de prof organische chemie- een LD50 (dosis waar 50% van de mensen van sterven) van 12 liter.


Diezelfde goede man heeft ook sappige anecdotes vertelt over de gezonde (ahum) competitie tussen verschillende firma's. Saccharine, cyclamaat, aspartaam,... telkens werden door de concurrentie ratten kaalgeschoren en volgesmeerd met die brol in zulke doses dat ze wel kanker moesten krijgen.

De vraag is of aspartaam in normale doses kanker kan veroorzaken. Een redelijk recente review in Annals of Oncology (een vakblad, itt tot de Guardian) meent dat het nog te vroeg is om conclusies te trekken, maar verklaart dat het risico verwaarloosbaar is.

http://annonc.oxfordjournals.org/cgi...15/10/1460.pdf

En het is slechter voor je tanden ;-)

Daarom drink ik dan ook koffie, bier en wijn.