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#21 |
Perm. Vertegenwoordiger VN
Geregistreerd: 17 februari 2003
Berichten: 11.300
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![]() heb ik het of heb ik het? Ne topic over drugs en succes is verzekerd! Er is hier zelf een apart lopende topic over noord-zuidtransfers! Hela!
De reden waarom de vijf organisaties de drugswet willen vernietigen is natuurlijk niet dezelfde als die van het Blok maar het Blok (en de CD&V en niveanen) had de regering gewaarschuwd dat deze wet van alle kanten mangelde! en we krijgen gelijk! Laten we dus de pro en contradrugs discussie niet herbeginnen! er lopen hierover al 10talle topics! |
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#22 | |
Perm. Vertegenwoordiger VN
Geregistreerd: 20 augustus 2002
Locatie: Antwerpen, 't Stad van Alleman
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"Ik bewandel het rechte pad dat, zoals u weet, niet bestaat en ook niet recht is." (Fred Vargas in 'Un lieu incertain' - 2008) |
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#23 | ||
Perm. Vertegenwoordiger VN
Geregistreerd: 17 februari 2003
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#24 | |
Banneling
Geregistreerd: 22 mei 2003
Locatie: Brussel
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#25 |
Banneling
Geregistreerd: 22 mei 2003
Locatie: Brussel
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#26 | |||
Perm. Vertegenwoordiger VN
Geregistreerd: 20 augustus 2002
Locatie: Antwerpen, 't Stad van Alleman
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![]() Voeg daar nog bij: grijze maurice, schele fons en zotte gust en je hebt de vijf oprichters van het VB in 1979 opgenoemd 8)
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"Ik bewandel het rechte pad dat, zoals u weet, niet bestaat en ook niet recht is." (Fred Vargas in 'Un lieu incertain' - 2008) |
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#27 | |||
Schepen
Geregistreerd: 22 juli 2002
Locatie: Varese (Noord-Italië) en nu weer Brussel
Berichten: 468
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- de Nederlandse wet laat geen productie, handel en gebruik toe: - productie wordt voor eigen gebruik als allerlaatste vervolgingsprioriteit gezien, dus in de praktijk zelden of nooit vervolgd (tenzij d epolitie je wil klissen om andere redenen, dan zullen ze dit als stok achter de deur nemen en dat lukt ook! vandaar trouwens dat ik altijd zeg dat de drugwet en het prohibitionisme door haar willekeur ook een politiek wapen is) - productie voor derden wordt als hogere prioriteit gezien en is dus vaker vervolgd! - kleinhandel (in coffeeshops) wordt gedoogd ondr zeer strenge voorwaarden - groothandel wordt beteugeld - gebruik wordt gedoogd, maar overlast niet: bovendien kan een cannabisgebruiker altijd nog vervolgd worden oor drugbezit (laagste prioriteit maar WEL MOGELIJK !!! - import en export zijn verboden (vandaar dat heel wat Belgische, duitse en Franse gebruikers aan de grens geklist worden.. Heel wat coffeeshopeigenaars in de grensgemeenten werken trouwens met de politie en doeane mee en geven NA verkoop tips, zodat de gebruikers even later aan het station aangehouden worden ! Los daarvan, een drugbeleid dat enkel rond cannabis geaxeerd is, erkt langs geen kanten: er is nodo aan één coherent drugbeleid, ongeacht het product (dat imemrs weinig betekenis heeft, ook l is harmreduction per product verschillend omdat je sommige producten bijvoorbeeld gemakkelijker kan roken dan een ander... ) Ik ken de ontwikkeling van het Nederlands drugbeleid redelijk goed aangezien ik het bestudeerd heb voor min doctoraat en ook samen met de gebruikersgroepen in één van de adviescommissie svan de Paarse drugsnota heb gezeten en nog steeds actie flid ben van het L.O.G. (landelijk Overleg Gebruikers, de koepelorganisatie van alle druggebruikersr oganisaties in Nederland).
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"Only two things are infinite, the universe and human stupidity, and I'm not sure about the former." (Albert Einstein) "I gained nothing at all from Supreme Enlightenment, and for that very reason it is called Supreme Enlightenment." (Boedha) |
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#28 | ||||
Banneling
Geregistreerd: 22 mei 2003
Locatie: Brussel
Berichten: 49.496
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ik denk aan de studie vorig jaar in het BMJ gepubliceerd werd (en soortgelijke waarschuwingen van de Académie Française de Médecine): bmj.com/cgi/content/full/325/7374/1183 Gemakkelijk te Googlen met de woorden <bmj cannabis mental health cohort> Papers [size=5]Cannabis use and mental health in young people:[/size] cohort study George C Patton, Carolyn Coffey, John B Carlin, Louisa Degenhardt, Michael Lynskey,Wayne Hall Abstract Objective To determine whether cannabis use in adolescence predisposes to higher rates of depression and anxiety in young adulthood. Design Seven wave cohort study over six years. Setting 44 schools in the Australian state of Victoria. Participants A statewide secondary school sample of 1601 students aged 14�*15 followed for seven years. Main outcome measure Interview measure of depression and anxiety (revised clinical interview schedule) at wave 7. Results Some 60% of participants had used cannabis by the age of 20; 7% were daily users at that point. Daily use in young women was associated with an over fivefold increase in the odds of reporting a state of depression and anxiety after adjustment for intercurrent use of other substances (odds ratio 5.6, 95% confidence interval 2.6 to 12).Weekly or more frequent cannabis use in teenagers predicted an approximately twofold increase in risk for later depression and anxiety (1.9, 1.1 to 3.3) after adjustment for potential baseline confounders. In contrast, depression and anxiety in teenagers predicted neither later weekly nor daily cannabis use. Conclusions Frequent cannabis use in teenage girls predicts later depression and anxiety, with daily users carrying the highest risk. Given recent increasing levels of cannabis use, measures to reduce frequent and heavy recreational use seem warranted. Introduction After increases in cannabis use during the early 1990s, a majority of young people in the United Kingdom, United States, New Zealand, and Australia now use cannabis recreationally.1 2 Despite the high prevalence of cannabis use, uncertainty persists about its physical and psychological consequences.3 Among the most prominent concerns have been putative links between use of cannabis and mental dis�* orders. A large intake of cannabis seems able to trigger acute psychotic episodes and may worsen outcomes in established psychosis.4 5 Associations with non�* psychotic disorders have received less attention. Yet evidence for an association between cannabis use and depression and anxiety has grown.6 Chronic daily users report high levels of anxiety, depression, fatigue, and their motivation is low.7 In one recent survey of young adults, over a third reported symptoms of anxiety that were associated with cannabis use; young women reported these more commonly.8 Cross sectional asso�* ciations between cannabis use and depression and anxiety have now been reported in surveys in both adolescents and adults,9 10 although not all studies have found an association in male participants.11 Questions remain about the level of association between cannabis use and depression and anxiety and about the mechanism underpinning the link. Pre�* existing symptoms might raise the likelihood of canna�* bis use through a mechanism of self medication.12 Alternatively, cannabis use may be more likely in people with a background of social adversity or particular characteristics—factors that might also raise risks for mental disorders. Cannabis may also carry a direct risk for depression and anxiety. We examined the risks for later depression and anxiety associated with cannabis use in teenagers. Spe�* cifically, the study addressed three questions. Firstly, does cannabis use in adolescents predict the develop�* ment of symptoms of depression and anxiety in young adults? Secondly, do symptoms of depression and anxiety in adolescence predict cannabis use in young adults? Thirdly, is any relation explained by factors such as family background or intercurrent use of other substances? Methods Sample Between August 1992 and December 1998 we conducted a seven wave cohort study of adolescent health in the Australian state of Victoria. The cohort was defined in a two stage cluster sample, in which we selected two classes at random from each of 44 schools drawn from a stratified frame of government run, Catholic, and independent schools (total number of students 60 905). School retention rates to year nine in the year of sampling were 98%. One class from each school entered the cohort in the latter part of the ninth school year (wave 1) and the second class six months later, early in the 10th school year (wave 2). Participants were subsequently reviewed at six month intervals for the next two years (waves 3 to 6), with a final follow up (wave 7) at the age of 20�*21, three years after the final school year in Victoria. In waves 1 to 6, participants self administered the questionnaire on laptop computers,13 and those absent from school were followed up by tele�* Editorial by Rey and Tennant Papers pp 1199, 1212 Centre for Adolescent Health, Murdoch Children's Research Institute, Parkville, Victoria 3052, Australia George C Patton professor of adolescent health Carolyn Coffey epidemiologist Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute John B Carlin director of unit National Drug and Alcohol Research Centre, University of New South Wales, Sydney 2052, Australia Louisa Degenhardt research fellow Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA Michael Lynskey visiting research fellow Office of Public Policy and Ethics, Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia Wayne Hall professor of bioethics Correspondence to: G Patton gpatton@cryptic. rch.unimelb.edu.au BMJ 2002;325:1195–8 1195 BMJ VOLUME 325 23 NOVEMBER 2002 bmj.com phone. The seventh wave of data collection used com�* puter assisted telephone interviews. All stages of the study were approved by the ethics committee of the Royal Children's Hospital. From a total sample of 2032 students, 1947 (95.8%) participated at least once during the first six (adolescent) waves. In wave 7, 1601 young adults (79% of the initial sample or 82% of teenage participants) were interviewed between April and December 1998. Response rates are shown in figure 1. Reasons for non�* completion at follow up were refusal (n=152), loss of contact (n=192), and death (n=2). We examined characteristics of non�*completers in a logistic regression model. Male participants were over�* represented (odds ratio 1.9, 95% confidence interval 1.5 to 2.4), as were parental divorce or separation (1.8, 1.4 to 2.5), and daily tobacco smoking at study inception (2.1, 1.5 to 2.9). Neither teenage depression and anxiety nor cannabis use were independently associated with loss to follow up. The mean age at wave 1 was 14.5 (SD 0.5) years; at wave 7 it was 20.7 (0.5) years. Of the 1601 participants in wave 7, 1130 (71%) still lived at home, 429 (27%) lived with others, and 42 (3%) lived alone. A total of 1345 (82%) had completed the final year of school; 1355 (85%) had started post�*school study. Measures We used the computerised revised clinical interview schedule (CIS�*R) to assess depression and anxiety at each wave.14 The schedule provides data on the frequency, severity, persistence, and intrusiveness of 14 common psychiatric symptoms and has been widely used in population based surveys.15 A total score of 12 or greater was taken to define a mixed state of depres�* sion and anxiety at a lower threshold than syndromes of major depression and anxiety disorder but one where clinical intervention would still be appropriate.16 We assessed cannabis use on the basis of self reported frequency of use in the previous six months in waves 1 to 6 and in the previous 12 months in wave 7. This allowed classification as never used, less than weekly use, at least weekly use, and daily use (defined as using on five or more days per week), and initiation after wave 6. We assessed use of alcohol, tobacco, and other illicit drugs (including ecstasy, heroin, amphetamines, LSD, and steroids) on the basis of self reported frequency of use and with retrospective diaries over seven days for participants reporting recent drinking or smoking. Participants drinking on three or more days in the pre�* vious week were classified as frequent drinkers. We assessed antisocial behaviour in waves 1 to 6 by using items from the self reported early delinquency scale that covered property damage, interpersonal vio�* lence, and theft.17 Analysis We collected data at a developmental point when young people are difficult to trace because of high mobility. Although the response rate was high and attrition low, 70% of respondents missed at least one wave of data collection, which led to potential bias in summary measures of exposure to cannabis and mental health problems calculated from the six waves of data collection among adolescents. To circumvent this, we used multiple imputation with five complete datasets created by imputation under the multivariate mixed effects model of Schafer and Yucel, incorporat�* ing the covariates sex, age, rural or urban residence, and parental education (available for all partici�* pants).18 19 These covariates were strongly associated with missingness, and the model incorporated a random effects structure to accommodate correlation within participants over time.We constructed principal measures by classifying participants according to whether they fell into categories of interest at least once during wave 1 to 6 (adolescence) and, separately, in wave 7 (young adulthood). Data analysis was performed with Stata 7. We modelled associations by univariate and multivariate logistic regression analyses and usedWald tests and related confidence intervals to assess statistical significance and precision. Results Altogether 71 male participants (9.7%, 95% confidence interval 7.5% to 12%) and 188 (22%, 19% to 25%) of female participants reported depression and anxiety as young adults (odds ratio 2.6, 1.9 to 3.5). Sixty six per cent (484/731) of male participants and 52% (448/859) of female participants reported using cannabis at some time (11 participants did not respond to this question), with three quarters starting use when they were teenagers. Twenty per cent (146; 17% to 22%) of male participants and 8% (69; 6% to 10%) of female participants were using cannabis at least weekly, with 10% (73; 8% to 12%) of young men and 4% (37; 3% to 6%) of young women using it daily. Cannabis and depression in young adults The prevalence of depression and anxiety increased with higher extents of cannabis use, but this pattern was clearest in female participants (table 1). We used logistic regression to analyse the level of association between depression and anxiety and cannabis use in young adults (table 2) after adjustment for concurrent substance use. We found a significant interaction between sex and daily cannabis use. In the adjusted model, young women who used cannabis daily had an over fivefold increase in the odds of depression and anxiety found in non�*users. Cannabis in adolescence and depression in young adults We used logistic regression to examine the prediction of depression and anxiety in young adults by cannabis use in adolescence. In the univariate analysis a dose response was evident: daily use in female teenagers 1st sample (n=1037) Wave 1 (n=898; 87%) late 1992 2nd sample (n=995) Total intended sample (n=2032) Total achieved sample (n=1947; 96%) Wave 2 (n=1728; 85%) early 1993 Wave 3 (n=1699; 84%) late 1993 Wave 4 (n=1629; 80%) early 1994 Wave 5 (n=1576; 78%) late 1994 Wave 6 (n=1530; 75%) early 1995 Wave 7 (n=1601; 79%) 1998 Young adult survey Adolescent phase Fig 1 Participation rates of 2032 secondary school students in the Victorian adolescent health cohort study. The percentages in waves 2�*7 are the proportions of the total intended sample for which complete data were collected Papers 1196 BMJ VOLUME 325 23 NOVEMBER 2002 bmj.com predicted fourfold higher odds of later depression and anxiety (odds ratio 4.2, 1.6 to 11), weekly use a twofold elevation (2.3, 1.3 to 4.2). In the multivariate model we collapsed the top categories of cannabis use (table 3). The interaction between sex and weekly or more frequent use was significant. An almost twofold increase in risk for weekly or more frequent users who were female persisted after adjustment for potential confounders. Depression in adolescence and cannabis in young adults We considered whether depression and anxiety in ado�* lescence predicted later cannabis use in young adulthood in two further logistic regression models, examining the predictions of weekly and daily use (table 4). After adjustment for adolescent cannabis use and other potential confounders, adolescent depres�* sion and anxiety predicted neither weekly nor daily use. Discussion Around 60% of the statewide secondary school sample had used cannabis recreationally by young adulthood; most participants first experimented while at second�* ary school. By young adulthood 7% were daily users and in young women this level of use was associated with over five times the odds of depression and anxiety found in non�*users. In young women, weekly use as teenagers predicted a twofold increase in later depres�* sion and anxiety and daily use a fourfold increase. In contrast, depression in teenagers did not predict higher cannabis use. Strengths Earlier cohort studies had a limited capacity to address the key questions of this study. One study reported a prospective relation between cannabis use and later depression but started well after the risk period of onset for both.20 Two important studies in adolescence examined either monthly cannabis use or use in the preceding year—doses that in the light of this study are unlikely to be associated with mental health problems.21 22 Our close to representative sample, high rates of participation, and frequent measures during partici�* pants' teenage years are strengths of this study. A tele�* phone interview strategy was used in data collection in the last wave, and, although prevalence estimates may vary slightly as a result, it is unlikely to have caused a systematic bias in patterns of association. The use of multiple imputation minimised measurement biases arising from missing data during the teenage years, but we did not attempt to adjust for differential participation of young adults. Even though depression and anxiety in teenagers and cannabis use did not pre�* dict dropout from the study, the difference in non�*responders on other factors (for example, sex or family structure) may have had some bearing on the specification of associations. What the results might mean Possible explanations for the high degree of depres�* sion and anxiety found in young women who used cannabis often include underlying characteristics that predispose to both anxiety and depression, self medication of pre�*existing depressive symptoms, and an adverse effect of cannabis on mental health.21 The association with cannabis use persisted after adjust�* ment for concurrent use of alcohol, tobacco, and other illicit substances as well as indices of family disadvantage—findings consistent with a more direct relation. We considered self medication with cannabis Table 1 Prevalence of depression and anxiety according to cannabis use by sex in 1590 young adults in wave 7 (n=1601) of the Victorian adolescent health cohort study Frequency of cannabis use in previous 12 months Men Women No % (95% CI) Odds ratio* (95% CI) No % (95% CI) Odds ratio* (95% CI) None to <5 times ever 523 9 (6 to 11) (1) 744 19 (17 to 22) (1) 5 times ever to less than weekly 62 10 (2 to 17) 1.1 (0.46 to 2.8) 46 17 (6 to 29) 0.87 (0.40 to 1.9) 1 to 4 times per week 73 12 (5 to 20) 1.5 (0.70 to 3.2) 32 31 (14 to 48) 1.9 (0.87 to 4.1) Daily 73 15 (7 to 23) 1.9 (0.93 to 3.8) 37 68 (52 to 83) 8.6 (4.2 to 18) *Obtained from univariate logistic regression models. 11 (7 female) participants in wave 7 did not answer the questions about cannabis use. *Obtained from univariate logistic regression models. Table 2 Association between cannabis use in the previous 12 months and depression and anxiety in 1590 young adults in wave 7 (n=1601) of the Victorian adolescent health study, derived from a multivariate logistic model Cannabis use No Adjusted odds ratio (95% CI) None to <5 times in previous 12 months 1267 1 5 times ever to <weekly 108 0.80 (0.44 to 1.5) 1�*4 times/week 105 1.1 (0.60 to 2.0) Daily*: Men 73 1.1 (0.55 to 2.6) Women 37 5.6 (2.6 to 12) Female sex in the absence of daily cannabis use 822 2.5 (1.8 to 3.4) Odds ratios are adjusted for parental separation, parental education, current smoking, frequency of drinking, and use of other illicit drugs. 11 (7 female) participants did not answer the questions about cannabis use in wave 7. *Wald test for interaction between daily cannabis use and sex: P=0.003. Table 3 Association of cannabis use in teenagers with later depression and anxiety in 1601 young adults in wave 7 of the Victorian adolescent health cohort study Measures in waves 1�*6 No* Unadjusted odds ratio (95% CI) Adjusted odds ratio (95% CI)�* Depression and anxiety (at least one wave) 744 6 (4.3 to 8.4) 5.1 (3.6 to 7.3) Maximal cannabis use None 1083 1 1 <Weekly 332 1.5 (1.1 to 2.1) 1.4 (94 to 2.0) >Weekly‡: Male teenagers 108 0.62 (0.24 to 1.6) 0.47 (0.17 to 1.3) Female teenagers 78 2.6 (1.6 to 4.3) 1.9 (1.1 to 3.3) Female sex in the absence of >weekly cannabis use 788 2.3 (1.6 to 3.1) 1.6 (1.1 to 2.3) *Numbers for adolescent cannabis use and depression and anxiety were estimated from five imputed datasets. �*Odds ratios by the highest frequency of cannabis use in teenagers (waves 1 to 6), obtained by using a multivariate logistic model, adjusted for teenagers' depression and anxiety, alcohol use, antisocial behaviour, parental separation, and parental education. ‡Wald test for interaction between more frequent than weekly cannabis use and sex: unadjusted P<0.001, adjusted P=0.011. Papers 1197 BMJ VOLUME 325 23 NOVEMBER 2002 bmj.com but found no prospective relation between depression and anxiety in adolescence and later frequent cannabis use, consistent with an earlier report.22 The persistence of associations in the multivariate models and the evidence for a prospective dose�* response relation are consistent with a view that frequent use of cannabis in young people increases the risks of later depression and anxiety. Psychosocial mechanisms—for example, the adoption of a counter�* cultural lifestyle—possibly underlie the association. Social consequences of frequent use include edu�* cational failure, dropout, unemployment, and crime— all factors that may lead to higher rates of mental disorders. Because risks seem confined largely to daily users, however, the question about a direct pharmaco�* logical effect remains. Cannabinoid receptors (CB1) are found widely in the central nervous system, with a distribution that is consistent with effects on a wide range of brain functions including memory, emotion, cognition, and movement.23 Cannabis use in young people remains a controver�* sial area, and absence of good data has handicapped the development of rational public health policies.3 These findings contribute to evidence that frequent cannabis use may have a deleterious effect on mental health beyond a risk for psychotic symptoms. Strategies to reduce frequent use of cannabis might reduce the level of mental disorders in young people. Contributors: GCP was the principal investigator and prepared the manuscript. CC was the study coordinator and contributed to data analysis and manuscript preparation. JBC contributed to the data analysis and manuscript preparation. LD,ML, and WH contributed to the preparation of the manuscript. GCP is the guarantor. Funding: National Health and Medical Research Council and Victorian Health Promotion Foundation. Competing interests: None declared. 1 Smart RG, Ogborne AC. Drug use and drinking among students in 36 countries. Addict Behav 2000;25:455�*60. 2 Ramsay, M, Spiller J. Drug use declared in 1996: latest results from the British crime survey. London: Home Office, 1977. 3 Strang J, Witton J, Hall W. Improving the quality of the cannabis debate: defining the different domains. BMJ 2000;320:108�*10. 4 Linszen DH, Dingemans PM, Lenior ME. Cannabis abuse and the course of recent�*onset schizophrenic disorders. Arch Gen Psychiatry 1994;51:273�*9. 5 Hall W. Cannabis use and psychosis. Alcohol Rev 1998;17:433�*44. 6 Degenhardt L, Hall W, Lynskey MT. Alcohol, cannabis and tobacco use among Australians: a comparison of their associations with other drug use and use disorders, affective and anxiety disorders, and psychosis. Addiction 2001;96:1603�*14. 7 Reilly D, Didcott R, Swift W. Long�*term cannabis use: characteristics of users in Australian rural areas. Addiction 1998;93:837�*46. 8 Thomas H. A community survey of adverse effects of cannabis use. Drug Alcohol Depend 1996;42:201�*7. 9 Rey JM, Sawyer MG, Raphael B, Patton GC, Lynskey MT. The mental health of teenagers who use marijuana. Br J Psychiatry 2001;180:216�*21. 10 Troisi A, Pasini A, Saracco M. Psychiatric symptoms in male cannabis users not using other illicit drugs. Addiction 1998;93:487�*92. 11 Green BE, Ritter C. Marijuana use and depression. J Health Soc Behav 2000;41:40�*9. 12 Paton S, Kessler R, Kandel D. Depressive mood and adolescent illicit drug use: a longitudinal analysis. J Gen Psychol 1977;92:267�*87. 13 Paperny DM, Aono JY, Lehman RM. Computer assisted detection and intervention in adolescent high�*risk health behaviour. J Pediatr 1990;116:456�*62. 14 Lewis G, Pelosi AJ. The manual of CIS�*R. London: Institute of Psychiatry, 1992. 15 Bebbington PE, Dunn G, Jenkins R, Lewis G, Brugha TS, Farrell M, et al. The influence of age and sex on the prevalence of depressive conditions: report from the national survey of psychiatric morbidity. Psychol Med 1998;28:9�*19. 16 Lewis G, Pelosi AJ, Araya R, Dunn G. Measuring psychiatric disorder in the community: a standardized assessment for use by lay interviewers. Psychol Med 1992;22:465�*86. 17 Moffitt TE, Silva PA. Self�*reported delinquency: results from an instrument for New Zealand. Aust N Z J Criminol 1988;21:227�*40. 18 Rubin DB. Multiple imputation for non�*response in surveys. New York:Wiley, 1987. 19 Schafer JL, Yucel RM. Computational strategies for multivariate linear mixed�*effects models with missing values. J Comput Graph Stat 2002;11:437�*57. 20 Bovasso GB. Cannabis abuse as a risk factor for depressive symptoms. Am J Psychiatry 2001;158:2033�*7. 21 Fergusson DM, Horwood LJ. Early onset cannabis use and psychosocial adjustment in young adults. Addiction 1997;92:279�*96. 22 McGee R, Williams S, Poulton RG, Moffitt TE. A longitudinal study of cannabis use and mental health from adolescence to early adulthood. Addiction 2000;95:491�*503. 23 Ameri A. The effects of cannabinoids on the brain. Prog Neurobiol 1999;58:315�*48. (Accepted 15 August 2002) Table 4 Association of cannabis use in teenagers (waves 1�*6) with later depression and anxiety in 1590 young adults in wave 7 (n=1601) of the Victorian adolescent health cohort study Measures in waves 1 to 6 No* Odds ratio (95% CI)�* >Weekly use Daily use Depression and anxiety: at least one wave 739 1.2 (0.86 to 1.8) 1.3 (0.80 to 2.2) Maximal cannabis use: None 1074 1 1 <Weekly 330 3.7 (2.4 to 5.6) 3.1 (1.7 to 5.7) >Weekly 185 15 (9.2 to 23) 15 (8.2 to 27) Female sex 859 0.38 (0.26 to 0.54) 0.5 (0.29 to 0.77) 11 (7 female) participants in wave 7 did not answer the questions about cannabis use. *Numbers for adolescent cannabis use and depression and anxiety estimated from five imputed datasets. �*Odds ratios obtained by using multivariate logistic models, adjusted for teenagers' cannabis use, drinking frequency, parental separation, and parental education. What is already known on this topic Frequent recreational use of cannabis has been linked to high rates of depression and anxiety in cross sectional surveys and studies of long term users Why cannabis users have higher rates of depression and anxiety is uncertain Previous longitudinal studies of cannabis use in youth have not analysed associations with frequent cannabis use What this study adds A strong association between daily use of cannabis and depression and anxiety in young women persists after adjustment for intercurrent use of other substances Frequent cannabis use in teenage girls predicts later higher rates of depression and anxiety Depression and anxiety in teenagers do not predict later cannabis use; self medication is therefore unlikely to be the reason for the association Endpiece Surgical innovation It is infinitely better to transplant a heart than to bury it so it can be devoured by worms. Christiaan Barnard (1922�*2001), who performed the first human heart transplant in 1967 Submitted by Max Edwards, surgical trainee, London Papers 1198 BMJ VOLUME 325 23 NOVEMBER 2002 bmj.com |
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#29 | |||
Banneling
Geregistreerd: 22 mei 2003
Locatie: Brussel
Berichten: 49.496
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#30 | |
Banneling
Geregistreerd: 22 mei 2003
Locatie: Brussel
Berichten: 49.496
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Niet belachelijk doen, als morgen jouw het zwartblok het telefoonboek overschrijft, en verklaart dat dat een lijst van telefoonbezitters is of zegt dat je moet kunnen zwemmen om niet te verdrinken of zo, dan heben ze ook gelijk: open deuren instampen heet dat bij mij, en ze zijn wel zo slim om tussen al hun (expletive deleted) propaganda en standpunten een aantal van die open deuren te schuiven, kwestie van "redelijk" over te komen bij de brave mensen: Hitlar zag ook graag kleine kindjes en huisdieren...! |
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#31 | ||||
Secretaris-Generaal VN
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![]() of zat je weer een jointje te paffen ! In die tijd moesten die zakenmensen studeren !
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Stop het geknoei ! Vlaanderen op eigen kracht ! Volk wordt staat. Vlaanderen mijn land. Vlaanderen onafhankelijk. Gedaan met geven en toegeven ! 12 miljard euro Vlaams geld in Vlaamse handen ! Mooie woorden zijn zelden waar, ware woorden zijn zelden mooi. "Niets lijkt zo op fascisten als de huidige antifascisten. Nultolerantie is een begin, rechtbank het einde. "De mening van een moslim heet geloofsovertuiging, die van een Vlaming is racisme. |
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#32 | |
Perm. Vertegenwoordiger VN
Geregistreerd: 17 februari 2003
Berichten: 11.300
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#33 |
Parlementsvoorzitter
Geregistreerd: 12 augustus 2002
Locatie: Limburg
Berichten: 2.261
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![]() Er zijn toch nog altijd mensen die denken dat België een democratie is.
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Democraat in hart en nieren. http://users.telenet.be/brov Laatst bijgewerkt op 09/2011 |
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#34 | ||
Banneling
Geregistreerd: 22 mei 2003
Locatie: Brussel
Berichten: 49.496
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