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Banneling
Geregistreerd: 5 maart 2004
Berichten: 4.052
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Citaat:
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Oorspronkelijk geplaatst door voicelesscharlie
Tamiflu is gewoon een krachtige virusremmer.
Tegen de vogelgriep zelf bestaat er nog geen middel maar het bedrijf Biocryst Pharming([size=1]ondertussen 16% gestegen vandaag  [/size]) is er één aan het maken. |
wat een onzin toch.
hoe kun je nu iets maken tegen een hybride die nog moet ontstaan door recombinatie tss. menselijke griep en vogelpest ?
vogelpest an sich is heel ongevaarlijk. In 3 jaar zijn er wereldwijd in totaal 100 mensen aan gestorven, belachelijk laag gewoon.
http://news.yahoo.com/s/nm/20051014/...NlYwMlJVRPUCUl
Citaat:
Bird flu virus shows signs of evading newest drug
By Maggie Fox, Health and Science Correspondent1 hour, 39 minutes ago
The feared avian influenza virus is showing signs it can evade the drug considered the first line of defense against bird flu, researchers said on Friday.
They found so-called resistant strains in a Vietnamese girl who recovered from a bird flu infection after being treated with Tamiflu. They also found evidence she was directly infected by her brother and not by chickens, a rare case of human-to-human transmission of the virus.
When bacteria and viruses develop resistance to a drug, it means higher doses of the drug are needed to eradicate or control an infection. Ultimately it means the drug will stop working.
This has happened with many antibiotics, starting with penicillin, and is common among AIDS drugs.
The finding illustrates the need to find and use other drugs to treat influenza and to work quickly to develop a vaccine, the researchers said.
"I don't think we need to panic based on this finding," Yoshihiro Kawaoka of the University of Wisconsin-Madison, who led the study, said in a telephone interview.
But the report, to be published in the journal Nature next week, is bad news for doctors around the world who already have precious little in the arsenal against bird flu should it become a human disease.
"This is the first line of defense," Kawaoka said. "It is the drug many countries are stockpiling, and the plan is to rely heavily on it."
The H5N1 strain of avian influenza is considered by health experts to be the biggest single disease threat to the world. Since surfacing in Hong Kong in 1997, it has spread in flocks of poultry across Asia and is now in Turkey.
It does not yet move easily from birds to humans but it has infected 117 people in four Asian countries and has killed 60 of them, according to the World Health Organization.
WHO believes it will eventually acquire the ability to move easily from human to human and that when it does, it will cause a pandemic that will sweep the world in weeks or months and kill millions if not tens of millions of people.
STOCKPILING SUPPLIES
Countries are stockpiling supplies of Tamiflu, an antiviral drug known generically as oseltamivir invented by Gilead Sciences and made and marketed by Swiss drug giant Roche Holdings.
They are to a lesser degree buying up supplies of Relenza, developed by Australia's Biota Holdings and marketed by GlaxoSmithKline. Known generically as zanamivir, this drug is also effective against avian flu but is given via the nose and considered less desirable than a pill like Tamiflu.
An older flu drug called amantadine is already considered to be of little use against H5N1 avian influenza. Work is proceeding on a vaccine but flu vaccines take months to make and cannot be formulated until after an epidemic has begun because they must use the precise strain of virus circulating.
Kawaoka, who is also at the University of Tokyo, worked with colleagues in Japan and Vietnam to analyze samples of virus taken from a 14-year-old Vietnamese girl, called "patient 1," who recovered from an H5N1 infection last March.
"Patient 1 had not had any known direct contact with poultry, but had cared for her 21-year-old brother (patient 2) while he had a documented H5N1 virus infection," Kawaoka and colleagues wrote in their report,
She had been given Tamiflu three days before she became ill, and then was treated with the drug when it failed to prevent her infection.
Kawaoka's team found several types of H5N1 virus in the girl's sample, some of which had developed genetic mutations to make Tamiflu virtually worthless against it.
"It is a mixture," he said. "Within the mixture we found virus that is highly, highly resistant. When you look at the virus as a whole, it is partially resistant," Kawaoka said.
"I think what is important here is that the vast majority of H5N1 viruses are still very sensitive to oseltamivir," Kawaoka said.
"Although our findings are based on a virus from only a single patient, they raise the possibility that it might be useful to stockpile zanamivir as well as oseltamivir in the event of an H5N1 influenza pandemic," the researchers wrote. And it will be important to test the virus regularly to see if it is changing and becoming resistant to drugs, they said.
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[edit]
[size=1] Edit:[/size] [size=1]After edit by /\|cazar on 14-10-2005 at 23:17
Reason:
--------------------------------
Citaat:
|
Oorspronkelijk geplaatst door voicelesscharlie
Tamiflu is gewoon een krachtige virusremmer.
Tegen de vogelgriep zelf bestaat er nog geen middel maar het bedrijf Biocryst Pharming([size=1]ondertussen 16% gestegen vandaag [/size]) is er één aan het maken. |
wat een onzin toch.
hoe kun je nu iets maken tegen een hybride die nog moet ontstaan door recombinatie tss. menselijke griep en vogelpest ?
vogelpest an sich is heel ongevaarlijk. In 3 jaar zijn er wereldwijd in totaal 100 mensen aan gestorven, belachelijk laag gewoon.
http://news.yahoo.com/s/nm/20051014/...NlYwMlJVRPUCUl
Citaat:
Bird flu virus shows signs of evading newest drug
By Maggie Fox, Health and Science Correspondent1 hour, 39 minutes ago
The feared avian influenza virus is showing signs it can evade the drug considered the first line of defense against bird flu, researchers said on Friday.
They found so-called resistant strains in a Vietnamese girl who recovered from a bird flu infection after being treated with Tamiflu. They also found evidence she was directly infected by her brother and not by chickens, a rare case of human-to-human transmission of the virus.
When bacteria and viruses develop resistance to a drug, it means higher doses of the drug are needed to eradicate or control an infection. Ultimately it means the drug will stop working.
This has happened with many antibiotics, starting with penicillin, and is common among AIDS drugs.
The finding illustrates the need to find and use other drugs to treat influenza and to work quickly to develop a vaccine, the researchers said.
"I don't think we need to panic based on this finding," Yoshihiro Kawaoka of the University of Wisconsin-Madison, who led the study, said in a telephone interview.
But the report, to be published in the journal Nature next week, is bad news for doctors around the world who already have precious little in the arsenal against bird flu should it become a human disease.
"This is the first line of defense," Kawaoka said. "It is the drug many countries are stockpiling, and the plan is to rely heavily on it."
The H5N1 strain of avian influenza is considered by health experts to be the biggest single disease threat to the world. Since surfacing in Hong Kong in 1997, it has spread in flocks of poultry across Asia and is now in Turkey.
It does not yet move easily from birds to humans but it has infected 117 people in four Asian countries and has killed 60 of them, according to the World Health Organization.
WHO believes it will eventually acquire the ability to move easily from human to human and that when it does, it will cause a pandemic that will sweep the world in weeks or months and kill millions if not tens of millions of people.
STOCKPILING SUPPLIES
Countries are stockpiling supplies of Tamiflu, an antiviral drug known generically as oseltamivir invented by Gilead Sciences and made and marketed by Swiss drug giant Roche Holdings.
They are to a lesser degree buying up supplies of Relenza, developed by Australia's Biota Holdings and marketed by GlaxoSmithKline. Known generically as zanamivir, this drug is also effective against avian flu but is given via the nose and considered less desirable than a pill like Tamiflu.
An older flu drug called amantadine is already considered to be of little use against H5N1 avian influenza. Work is proceeding on a vaccine but flu vaccines take months to make and cannot be formulated until after an epidemic has begun because they must use the precise strain of virus circulating.
Kawaoka, who is also at the University of Tokyo, worked with colleagues in Japan and Vietnam to analyze samples of virus taken from a 14-year-old Vietnamese girl, called "patient 1," who recovered from an H5N1 infection last March.
"Patient 1 had not had any known direct contact with poultry, but had cared for her 21-year-old brother (patient 2) while he had a documented H5N1 virus infection," Kawaoka and colleagues wrote in their report,
She had been given Tamiflu three days before she became ill, and then was treated with the drug when it failed to prevent her infection.
Kawaoka's team found several types of H5N1 virus in the girl's sample, some of which had developed genetic mutations to make Tamiflu virtually worthless against it.
"It is a mixture," he said. "Within the mixture we found virus that is highly, highly resistant. When you look at the virus as a whole, it is partially resistant," Kawaoka said.
"I think what is important here is that the vast majority of H5N1 viruses are still very sensitive to oseltamivir," Kawaoka said.
"Although our findings are based on a virus from only a single patient, they raise the possibility that it might be useful to stockpile zanamivir as well as oseltamivir in the event of an H5N1 influenza pandemic," the researchers wrote. And it will be important to test the virus regularly to see if it is changing and becoming resistant to drugs, they said.
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[/size] |
[size=1] Edit:[/size] [size=1]After edit by /\|cazar on 14-10-2005 at 23:16
Reason:
--------------------------------
Citaat:
|
Oorspronkelijk geplaatst door voicelesscharlie
Tamiflu is gewoon een krachtige virusremmer.
Tegen de vogelgriep zelf bestaat er nog geen middel maar het bedrijf Biocryst Pharming([size=1]ondertussen 16% gestegen vandaag [/size]) is er één aan het maken. |
wat een onzin toch.
hoe kun je nu iets maken tegen een hybride die nog moet ontstaan door recombinatie tss. menselijke griep en vogelpest ?
vogelpest an sich is heel ongevaarlijk. In 3 jaar zijn er wereldwijd in totaal 100 mensen aan gestorven, belachelijk laag gewoon.
http://news.yahoo.com/s/nm/20051014/...NlYwMlJVRPUCUl[/size] |
[size=1] Edit:[/size] [size=1]After edit by /\|cazar on 14-10-2005 at 22:51
Reason:
--------------------------------
Citaat:
|
Oorspronkelijk geplaatst door voicelesscharlie
Tamiflu is gewoon een krachtige virusremmer.
Tegen de vogelgriep zelf bestaat er nog geen middel maar het bedrijf Biocryst Pharming([size=1]ondertussen 16% gestegen vandaag [/size]) is er één aan het maken. |
wat een onzin toch.
hoe kun je nu iets maken tegen een hybride die nog moet ontstaan door recombinatie tss. menselijke griep en vogelpest ?
vogelpest an sich is heel ongevaarlijk. In 3 jaar zijn er wereldwijd in totaal 100 mensen aan gestorven, belachelijk laag gewoon.[/size] |
[size=1]Before any edits, post was:
--------------------------------
Citaat:
|
Oorspronkelijk geplaatst door voicelesscharlie
Tamiflu is gewoon een krachtige virusremmer.
Tegen de vogelgriep zelf bestaat er nog geen middel maar het bedrijf Biocryst Pharming([size=1]ondertussen 16% gestegen vandaag [/size]) is er één aan het maken. |
wat een onzin toch.
hoe kun je nu iets maken tegen een hybride die nog moet ontstaan door recombinatie tss. menselijke griep en vogelpest ?
vogelpest an sich is heel ongevaarlijk. In 3 jaar zijn er in totaal 100 mensen aan gestorven, belachelijk laag gewoon.[/size] |
[/edit]
Laatst gewijzigd door /\|cazar : 14 oktober 2005 om 22:17.
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14 oktober 2005, 21:43
